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Old 27-02-2004, 12:22 PM
martin
 
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Default found a mouse in my loft!

On Fri, 27 Feb 2004 10:10:06 +0000, Thes
wrote:



Taking your advice led me to this, from the Inchem Chemical Safety pages:

4.4.1 Early symptoms of poisoning - Acute poisoning from a single dose
of warfarin is unlikely. On repeated exposure symptoms may
occur from the sixth or seventh day and include back and
abdominal pain followed by vomiting, nose and gum bleeding,
massive bruising and haematoma fomation.

I guess the fact that one source did not mention pain doesn't mean there
is none. But who knows, perhaps this info is wrong too!


After reading a lot of references on the Inchem site, I conclude that
if Haemarthrosis occurs first then there is pain, but if a coma
occurs first there isn't.

http://www.inchem.org/documents/pims...ical%20effects

Haemarthrosis may occur and cause
joint pain.

http://www.inchem.org/documents/hsg/...tionNumber:2.6

A WORLD HEALTH ORGANIZATION report

2.6 Effects on Laboratory Mammals and in vitro Test Systems

The acute oral toxicity of warfarin for rats is high. Reported
LD50
values range from 11 to 323 mg/kg, females being more susceptible
than
males. For classification purposes, the accepted WHO LD50 value is
10 mg/kg. Genetic resistance to warfarin among rodents and humans
has
been reported. Signs of poisoning are those associated with an
increased tendency to bleed.

One study on rats showed some developmental effects. There are no
data
on mutagenicity.

In feeding studies on rats, the only effect found was associated
with
anticoagulant action.

2.7 Effects on Humans

Vitamin K functions as an essential element in the synthesis of
several blood coagulation factors. Warfarin inhibits this process
and
consequently affects the blood coagulation mechanisms. Prolonged
inhibition of the vitamin K synthesis will lead to severe bleeding
and
death, if not corrected.

Symptoms of warfarin poisoning begin a few days or weeks after
ingestion. They include nose bleeding, bleeding gums, pallor, and,
sometimes, haematomas around joints and on the buttocks, and blood
in
the urine and faeces. Later, paralysis due to cerebral haemorrhage
and, finally, haemorrhagic shock and death may occur.

Poisoning incidents have been reported. Outbreaks of poisoning
have
been observed in relation to warfarin-contaminated meal and also
in
infants after dermal application of warfarin-contaminated talc. A
case
of poisoning from prolonged skin contact during the preparation of
warfarin baits has also been reported.

Developmental effects known as "warfarin embryopathy" or "fetal
warfarin syndrome" were reported when warfarin was administered as
a
therapeutic agent during pregnancy. No cases of embryopathy
following
the use of warfarin as a rodenticide have been reported.
--

Knowledge is knowing a tomato is a fruit;
Wisdom is not putting it in a fruit salad