found a mouse in my loft!
martin wrote: On Sun, 22 Feb 2004 14:42:44 +0000, Jack Hammer wrote: On Sun, 22 Feb 2004 14:37:15 -0000, "Mary Fisher" wrote: "Jack Hammer" wrote in message ... On Sun, 22 Feb 2004 13:47:21 -0000, "Mary Fisher" wrote: "Jack Hammer" wrote in message om... On Sun, 22 Feb 2004 11:14:03 +0100, martin wrote: On Sun, 22 Feb 2004 10:10:32 -0000, "Mary Fisher" wrote: "Jaques d'Alltrades" wrote in message . uk... Warfarin-based poisons are not particularly unpleasant. The victims just get weaker and weaker and lapse into a coma. The Warfarin tends to prevent the blood clotting, and the passage of food down the gut abrades the villi (a design feature to allow nutrients to be absorbed through the walls of the blood vessels) and the animal loses blood internally, and weakens and dies. There is no pain involved. How do you know? because it's used in humans as an anti clotting agent. The village idiot mentality is astounding! That sounds like the voice of experience. Using a substance medicinally is not the same as using it to kill. If you fed enough Warfarin to a human to kill him would it cause pain? Yes. It is a slow and agonizing death, rat or man would bleed to death from the inside. The fact that very minute doses of poison are used very successfully in medicine has nothing to do with it's use to kill something. Somebody said, "There is no pain involved." and I asked how that waas known. It seems now that there IS pain involved. Precisely. Now who's the idiot? The one who thinks there is no pain involved because grandad uses it to ease a heart condition! Both my granddads have been dead for decades, I said it caused no pain because when I googled for the symptoms of warfarin poisoning there is no mention of pain. Why let facts ruin a good argument, when it's so much easier to call somebody an idiot. Taking your advice led me to this, from the Inchem Chemical Safety pages: 4.4.1 Early symptoms of poisoning - Acute poisoning from a single dose of warfarin is unlikely. On repeated exposure symptoms may occur from the sixth or seventh day and include back and abdominal pain followed by vomiting, nose and gum bleeding, massive bruising and haematoma fomation. I guess the fact that one source did not mention pain doesn't mean there is none. But who knows, perhaps this info is wrong too! |
found a mouse in my loft!
On Fri, 27 Feb 2004 10:10:06 +0000, Thes
wrote: Taking your advice led me to this, from the Inchem Chemical Safety pages: 4.4.1 Early symptoms of poisoning - Acute poisoning from a single dose of warfarin is unlikely. On repeated exposure symptoms may occur from the sixth or seventh day and include back and abdominal pain followed by vomiting, nose and gum bleeding, massive bruising and haematoma fomation. I guess the fact that one source did not mention pain doesn't mean there is none. But who knows, perhaps this info is wrong too! After reading a lot of references on the Inchem site, I conclude that if Haemarthrosis occurs first then there is pain, but if a coma occurs first there isn't. http://www.inchem.org/documents/pims...ical%20effects Haemarthrosis may occur and cause joint pain. http://www.inchem.org/documents/hsg/...tionNumber:2.6 A WORLD HEALTH ORGANIZATION report 2.6 Effects on Laboratory Mammals and in vitro Test Systems The acute oral toxicity of warfarin for rats is high. Reported LD50 values range from 11 to 323 mg/kg, females being more susceptible than males. For classification purposes, the accepted WHO LD50 value is 10 mg/kg. Genetic resistance to warfarin among rodents and humans has been reported. Signs of poisoning are those associated with an increased tendency to bleed. One study on rats showed some developmental effects. There are no data on mutagenicity. In feeding studies on rats, the only effect found was associated with anticoagulant action. 2.7 Effects on Humans Vitamin K functions as an essential element in the synthesis of several blood coagulation factors. Warfarin inhibits this process and consequently affects the blood coagulation mechanisms. Prolonged inhibition of the vitamin K synthesis will lead to severe bleeding and death, if not corrected. Symptoms of warfarin poisoning begin a few days or weeks after ingestion. They include nose bleeding, bleeding gums, pallor, and, sometimes, haematomas around joints and on the buttocks, and blood in the urine and faeces. Later, paralysis due to cerebral haemorrhage and, finally, haemorrhagic shock and death may occur. Poisoning incidents have been reported. Outbreaks of poisoning have been observed in relation to warfarin-contaminated meal and also in infants after dermal application of warfarin-contaminated talc. A case of poisoning from prolonged skin contact during the preparation of warfarin baits has also been reported. Developmental effects known as "warfarin embryopathy" or "fetal warfarin syndrome" were reported when warfarin was administered as a therapeutic agent during pregnancy. No cases of embryopathy following the use of warfarin as a rodenticide have been reported. -- Knowledge is knowing a tomato is a fruit; Wisdom is not putting it in a fruit salad |
found a mouse in my loft!
On Fri, 27 Feb 2004 10:10:06 +0000, Thes
wrote: Taking your advice led me to this, from the Inchem Chemical Safety pages: 4.4.1 Early symptoms of poisoning - Acute poisoning from a single dose of warfarin is unlikely. On repeated exposure symptoms may occur from the sixth or seventh day and include back and abdominal pain followed by vomiting, nose and gum bleeding, massive bruising and haematoma fomation. I guess the fact that one source did not mention pain doesn't mean there is none. But who knows, perhaps this info is wrong too! After reading a lot of references on the Inchem site, I conclude that if Haemarthrosis occurs first then there is pain, but if a coma occurs first there isn't. http://www.inchem.org/documents/pims...ical%20effects Haemarthrosis may occur and cause joint pain. http://www.inchem.org/documents/hsg/...tionNumber:2.6 A WORLD HEALTH ORGANIZATION report 2.6 Effects on Laboratory Mammals and in vitro Test Systems The acute oral toxicity of warfarin for rats is high. Reported LD50 values range from 11 to 323 mg/kg, females being more susceptible than males. For classification purposes, the accepted WHO LD50 value is 10 mg/kg. Genetic resistance to warfarin among rodents and humans has been reported. Signs of poisoning are those associated with an increased tendency to bleed. One study on rats showed some developmental effects. There are no data on mutagenicity. In feeding studies on rats, the only effect found was associated with anticoagulant action. 2.7 Effects on Humans Vitamin K functions as an essential element in the synthesis of several blood coagulation factors. Warfarin inhibits this process and consequently affects the blood coagulation mechanisms. Prolonged inhibition of the vitamin K synthesis will lead to severe bleeding and death, if not corrected. Symptoms of warfarin poisoning begin a few days or weeks after ingestion. They include nose bleeding, bleeding gums, pallor, and, sometimes, haematomas around joints and on the buttocks, and blood in the urine and faeces. Later, paralysis due to cerebral haemorrhage and, finally, haemorrhagic shock and death may occur. Poisoning incidents have been reported. Outbreaks of poisoning have been observed in relation to warfarin-contaminated meal and also in infants after dermal application of warfarin-contaminated talc. A case of poisoning from prolonged skin contact during the preparation of warfarin baits has also been reported. Developmental effects known as "warfarin embryopathy" or "fetal warfarin syndrome" were reported when warfarin was administered as a therapeutic agent during pregnancy. No cases of embryopathy following the use of warfarin as a rodenticide have been reported. -- Knowledge is knowing a tomato is a fruit; Wisdom is not putting it in a fruit salad |
found a mouse in my loft!
On Fri, 27 Feb 2004 10:10:06 +0000, Thes
wrote: Taking your advice led me to this, from the Inchem Chemical Safety pages: 4.4.1 Early symptoms of poisoning - Acute poisoning from a single dose of warfarin is unlikely. On repeated exposure symptoms may occur from the sixth or seventh day and include back and abdominal pain followed by vomiting, nose and gum bleeding, massive bruising and haematoma fomation. I guess the fact that one source did not mention pain doesn't mean there is none. But who knows, perhaps this info is wrong too! After reading a lot of references on the Inchem site, I conclude that if Haemarthrosis occurs first then there is pain, but if a coma occurs first there isn't. http://www.inchem.org/documents/pims...ical%20effects Haemarthrosis may occur and cause joint pain. http://www.inchem.org/documents/hsg/...tionNumber:2.6 A WORLD HEALTH ORGANIZATION report 2.6 Effects on Laboratory Mammals and in vitro Test Systems The acute oral toxicity of warfarin for rats is high. Reported LD50 values range from 11 to 323 mg/kg, females being more susceptible than males. For classification purposes, the accepted WHO LD50 value is 10 mg/kg. Genetic resistance to warfarin among rodents and humans has been reported. Signs of poisoning are those associated with an increased tendency to bleed. One study on rats showed some developmental effects. There are no data on mutagenicity. In feeding studies on rats, the only effect found was associated with anticoagulant action. 2.7 Effects on Humans Vitamin K functions as an essential element in the synthesis of several blood coagulation factors. Warfarin inhibits this process and consequently affects the blood coagulation mechanisms. Prolonged inhibition of the vitamin K synthesis will lead to severe bleeding and death, if not corrected. Symptoms of warfarin poisoning begin a few days or weeks after ingestion. They include nose bleeding, bleeding gums, pallor, and, sometimes, haematomas around joints and on the buttocks, and blood in the urine and faeces. Later, paralysis due to cerebral haemorrhage and, finally, haemorrhagic shock and death may occur. Poisoning incidents have been reported. Outbreaks of poisoning have been observed in relation to warfarin-contaminated meal and also in infants after dermal application of warfarin-contaminated talc. A case of poisoning from prolonged skin contact during the preparation of warfarin baits has also been reported. Developmental effects known as "warfarin embryopathy" or "fetal warfarin syndrome" were reported when warfarin was administered as a therapeutic agent during pregnancy. No cases of embryopathy following the use of warfarin as a rodenticide have been reported. -- Knowledge is knowing a tomato is a fruit; Wisdom is not putting it in a fruit salad |
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