Thread: Roundup Unready
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Old 03-09-2003, 04:42 PM
paghat
 
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Default Roundup Unready

In article , "Henry Kuska"
wrote:

Recent (March 2002) research specifically concerning Roundup:

Title: Pesticide Roundup provokes cell division dysfunction at the level of
CDK1/cyclin B activation.

Authors: Marc, Julie; Mulner-Lorillon, Odile; Boulben, Sandrine; Hureau,
Dorothee; Durand, Gael; Belle, Robert

I am including the Author Address's so that one does not assume that this
was published by a fringe group:

Station Biologique de Roscoff, Universite Pierre et Marie Curie (UFR 937),
Centre National de la Recherche Scientifique (CNRS, UMR 7127), 29682,
Roscoff Cedex, FranceStation Biologique de Roscoff, Universite Pierre et
Marie Curie (UFR 937), Centre National de la Recherche Scientifique (CNRS,
UMR 7127), 29682, Roscoff Cedex,

Published in: Chemical Research in Toxicology, volumn 15, pages 326-331,
(March 2002).

Abstract: "To assess human health risk from environmental chemicals, we have
studied the effect on cell cycle regulation of the widely used
glyphosate-containing pesticide Roundup. As a model system we have used sea
urchin embryonic first divisions following fertilization, which are
appropriate for the study of universal cell cycle regulation without
interference with transcription. We show that 0.8% Roundup (containing 8 mM
glyphosate) induces a delay in the kinetic of the first cell cleavage of sea
urchin embryos. The delay is dependent on the concentration of Roundup. The
delay in the cell cycle could be induced using increasing glyphosate
concentrations (1-10 mM) in the presence of a subthreshold concentration of
Roundup 0.2%, while glyphosate alone was ineffective, thus indicating
synergy between glyphosate and Roundup formulation products. The effect of
Roundup was not lethal and involved a delay in entry into M-phase of the
cell cycle, as judged cytologically. Since CDK1/cyclin B regulates
universally the M-phase of the cell cycle, we analyzed CDK1/cyclin B
activation during the first division of early development. Roundup delayed
the activation of CDK1/cyclin B in vivo. Roundup inhibited also the global
protein synthetic rate without preventing the accumulation of cyclin B. In
summary, Roundup affects cell cycle regulation by delaying activation of the
CDK1/cyclin B complex, by synergic effect of glyphosate and formulation
products. Considering the universality among species of the CDK1/cyclin B
regulator, our results question the safety of glyphosate and Roundup on
human health."
-----------------------------------------------------------

H. Kuska comment: I would like to remind the reader that the wording had to
be approved by the editor and the referees. The editor of a scientific
journal is normally one of the top scientists in the field and the referees
are also a select group chosen for their contributions to the field.

Henry Kuska, retired

http://home.neo.rr.com/kuska/


Henry: Billo Shillo already discounted this one, along with every other
citation except one he personally liked which was generated by an avowed
Monsanto propogandist who was formerly a leader among Philip Morris
propoganda scientists.

-paghat the ratgirl

--
"Of what are you afraid, my child?" inquired the kindly teacher.
"Oh, sir! The flowers, they are wild," replied the timid creature.
-from Peter Newell's "Wild Flowers"
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