Natural products which a

1) Impossible, extremely difficult, or extremely expensive to synthesize
in bulk

2) Hard or inefficient to isolate from natural sources

3) Of commercial interest to pharmaceutical, vitamin, food, or cosmetic
industries

4) The biosynthetic pathway (genes) has been outlined BRBR

Pinon pine nuts, pignolis. I also second the motion on saffron and vanilla.
Iris,
Central NY, Zone 5a, Sunset Zone 40
"If we see light at the end of the tunnel, It's the light of the oncoming
train."
Robert Lowell (1917-1977)