This happened for the second time to my tomato plants. Upon reaching

maturity, they become yellowed on the tops of the older leaves.

On the underside of the leaves is a lot of raised bumps. They look to be
dead spots. It also moves to the rachis by the leaf.

Eventually it moves up to higher leaves on the plant.

I tried using the directed solution on a bottle of Schultz with active
ingredient:

Clarified Hydrophobic Extract of Neem Oil 70%.

It didn't work. The plants would live with this even up to the flowering
stage. Could they have been diseased seeds?

Thanks.