!Need Help
 

Hi Dears,
I have a Question..
No body knows why Colchicum Can continues its growth throught having
Colchicine?
!All of us know The colchicine is an anticancer & antimitosis
agent...so the question is that

!Need Help
 

In message . com,
Biotech-lover writes
Hi Dears,
I have a Question..
No body knows why Colchicum Can continues its growth throught having
Colchicine?
!All of us know The colchicine is an anticancer & antimitosis
agent...so the question is that

Since no-one else has answered.

Colchicum is not the only plant genus producing tubliin-binding agents.
The anti-cancer drugs from Catharanthus, Podophyllum and Taxus all work
in that way.

I can think of three ways in which Colchicum can avoid the toxic effects
of colchicine.

1) It may have modified tubilins which lack the binding site.
2) It may sequestrate colchicine physically in locations away from the
meristem, so that it doesn't affect the growth of Colchicum, but is
released when the plant is eaten.
3) It may sequestrate colchicine chemically, so that it doesn't affect
the growth of Colchicum, but is released when the plant is eaten
(compare with cyanogenic glyocosides in Rosaceae).

I don't know which, if any, of these explanations applies. You might be
able to find an answer with Google, but it doesn't seem to fall out
readily.
--
Stewart Robert Hinsley

!Need Help
 

Hi stewart..
Thanks for your help!
az you mentioned i couldn't fall out the answer readily..in Google
so it was My last & maybe best opportunity to find my answer
anyway If you can help me more I'll be glad my friend..
Good Luck

!Need Help
 

In message . com,
Biotech-lover writes
Hi stewart..
Thanks for your help!
az you mentioned i couldn't fall out the answer readily..in Google
so it was My last & maybe best opportunity to find my answer
anyway If you can help me more I'll be glad my friend..
Good Luck

I hope you haven't misunderstood me; what I've given you is speculation,
not an answer. It was offered in the hope that it might help by
providing a focus for subsequent investigation.
--
Stewart Robert Hinsley

!Need Help
 

yes,I understood you....
thanks anyway....

!Need Help
 

hi
i've read about ur question and one Chinese book says that Colchicum is
a kind of alkaloid, which is a kind of secondary metabolite that plants
produce..the alkaloid is hold in the laticiferous tube (a kind of
internal secretory structure) so this may be why it has no direct
effect on plant cells but are used to protect themselves, attract
insects(esp.entomoplily plants) or sth. like that..
its difficult for me to use english so i may not discribe it
accurately...u'd better look for some more info..

!Need Help
 

Hi ,thank you so much