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CJD deaths
Lotus wrote in message ... Diagnosis and incidence of prion (CJD) disease: a tetrospective archival survey with implications for future research Neurodegeneration vol 4 1995;357-368. CJ Bruton, RK Bruton, SM Gentleman, GW Roberts. Corsellis Collection Brain Bank, Dept of neuropathy, Runwell Hosp, Wickford, Essex. etc. Reliable identification of CJD in the UX has become essential following the suggestion that prion disease in cattle might transmit accidentally to humans who eat contaminated beef. recent data suggest that some cases f CJD may be conically unrecognized; in order to examine this proposal we reviewed all cases of dementia (n-1000+) collected between 1964 and 1990. We identified 19 cases of CJD of which only 11 were diagnosed before death. These 11 had a characteristic clinical history of CJD. Their brains showed little or no external abnormality. In contrast only 2 of the 8 clinically unrecognized cases had characteristic symptoms. The remaining six presented atypically; their illness lasted 3 years or more, motor signs were much less evidnt and simple dementia was the most promminent feature. the brains showed moderate or severe cereral atrophy. Our data indicate that only about 60% of prion disease cases with pathologically typical SE were identified clinically during life. This suggests that human prion disease may bemore common than previously supposed and that a further review of the epidemiology is required. http://sparc.airtime.co.uk/bse/scij.htm 11 of a thousand - 1.1% of all cases _were_ clinically diagnosed. {That's a huge number, considering 'sporadic' CJD is considered to affect 1 person per *million*, isn't it!} The sample from the SE is not representative of the entire UK population, we know that Scotland and the borders have low incidence of BSE, so we'll consider just those of the English population suffering from dementia, in order to get a rough indication of the number of CJD deaths a year, were 1.1% of cases clinically diagnosed as CJD, as stated in the (pre-1990!) S-E study. There are currently over 750,000 people in the UK with dementia. Regionally, this figure can be broken down: England 634,000 http://www.cf.ac.uk/news/02-03/020913.html CJD kills within months. 634,000 x 1.1% = 6,974 CJD (clinically diagnosed) deaths per year. But here are the official figures; Deaths.... sporadic....1990-2002 ..... 598 http://www.doh.gov.uk/cjd/stats/dec02.htm Something _seriously_ doesn't add up here. Are the real number of CJD deaths being hidden from us? no, because the number dying from dementia is pretty well known. If more of them are dying from CJD you have to explain why other forms of dementia are falling -- Jim Webster "The pasture of stupidity is unwholesome to mankind" 'Abd-ar-Rahman b. Muhammad b. Khaldun al-Hadrami' |
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