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Roundup Unready
Under further investigation, Roundup APPEARS to be fairly safe. But then
as I mentioned, so did DDT. I don't know about "when used as directed", but Roundup does have negative effects on the reproductive system at some level... Roundup Inhibits Steroidogenesis by Disrupting Steroidogenic Acute Regulatory (StAR) Protein Expression ENVIRONMENTAL HEALTH PERSPECTIVES, (2000 Aug) 108 (8) 769-76 Recent reports demonstrate that many currently used pesticides have the capacity to disrupt reproductive function in animals. Although this reproductive dysfunction is typically characterized by alterations in serum steroid hormone levels, disruptions in spermatogenesis, and loss of fertility, the mechanisms involved in pesticide-induced infertility remain undear. Because testicular Leydig cells play a crucial role in male reproductive function by producing testosterone, we used the mouse MA-10 Leydig tumor cell line to study the molecular events involved in pesticide-induced alterations in steroid hormone biosynthesis. We previously showed that the organochlorine insecticide lindane and the organophosphate insecticide Dimethoate directly inhibit steroidogenesis in Leydig cells by disrupting expression of the steroidogenic acute regulatory (StAR) protein. StAR protein mediates the rate-limiting and acutely regulated step in steroidogenesis, the transfer of cholesterol from the outer to the inner mitochondrial membrane where the cytochrome P450 side chain cleavage (P450scc) enzyme initiates the synthesis of all steroid hormones. In the present study, we screened eight currently used pesticide formulations for their ability to inhibit steroidogenesis, concentrating on their effects on StAR expression in MA-10 cells. In addition, we determined the effects of these compounds on the levels and activities of the P450scc enzyme (which converts cholesterol to pregnenolone) and the 3beta-hydroxysteroid dehydrogenase (3beta-HSD) enzyme (which converts pregnenolone to progesterone). Of the pesticides screened, only the pesticide Roundup inhibited dibutyryl [(Bu)2]cAMP-stimulated progesterone production in MA-10 cells without causing cellular toxicity. Roundup inhibited steroidogenesis by disrupting StAR protein expression, further demonstrating the susceptibility of StAR to environmental pollutants. Key words. chemical mixtures, cytochrome P450 side chain cleavage, environmental endocrine disruptor, 3beta-hydroxysteroid dehydrogenase, Leydig cells, Roundup, steroid hormones, steroidogenesis, steroidogenic acute regulatory protein. Environ Health Perspect 108:769-776 (2000). Bill Oliver wrote: In article , Tom Jaszewski newsgroup wrote: You tell em billbo...Yeah! after all what could some analytical chemist know about detrimental effects...end sarcasm You're turning into quite the little ankle-biter, aren't you, Tom. First you cyberstalk, then you try to use sock puppets and anonymity, and now you follow me around from thread to thread. OK, Tom, my challenge stands. One single scientific article in a peer-reviewed scientific journal that claims to show that Roundup is dangerous to humans when used as directed. One. Just one. billo -- Stephen Sassman |
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